Many results from mainstream biological research call into question the materialist narrative of the origin of life and macroevolution. At some point, as more and more evidence contradicting the materialist narrative accumulates, scientists will have to abandon the materialist view of biological history:
DNA sequence data falsifies common descent. An evolutionary tree can be constructed by comparing the same gene in different organisms but using different genes produce widely divergent trees.
Homologous genes that regulate analogous structures. Genes with similar sequences regulate similar features (Pax-6: eyes, GSK-3b: limbs, Csx/tinman: hearts, etc) that evolved independently in different organisms:
Missing evidence of precambrian fossils. Enough soft-bodied Precambrian fossils have been found for fossils of the ancestors to the animal types that appeared in the Cambrian explosion to have been found if they existed.
Information theory shows that random variation cannot produce information, randomness is noise it reduces information.